Saving the Sustainability of the European Union, Fighting Terrorism

Albeit the absence of an agreement on the definition, terrorism as studied in this literature has a complex nature and diverse factors that are involved. Furthermore, dealing with terrorism has become the centrepiece of foreign policies of many countries worldwide. The European Union has a long history of fighting terrorism. Yet, the current terrorism threats have shaken the bases of the Union. According to the authors’ assessment and evaluation, terrorism in Europe, in the aftermath of the Second World War, occurs due to the unsustainable foreign policies of the EU member states. To save the European Union and to fight terrorism, the authors suggest a framework based on four complementary headlines: i) Education, ii) Social justice and human rights, iii) Law enforcement, and iv) Sustainable common defence policy. A prerequisite to the success of this framework is a revision of the Europe-transatlantic relations to address the imbalance in the EU relations with USA

The economics of irrigating wheat in a humid climate - A study in the East of England

In the UK, wheat is the most important cultivated cereal, grown extensively as a rainfed crop. Irrigation of wheat has previously been considered uneconomic, but increases in world wheat prices and recent droughts have led to some farmers revising their views. Widespread adoption of wheat irrigation would have major implications for wheat production, the irrigation industry and water resources in regions that are already water scarce. This study investigated the financial viability of irrigating winter wheat grown on a sandy loam soil in the East of England. Long-term climate data (1961–2011) for Silsoe (Bedfordshire) was used to drive a biophysical crop model to assess irrigation water requirements and yield response. Modelling assumed a typical irrigation schedule to maximise yield and quality, and average reported wheat prices for 2007 to 2012. Irrigation costs were calculated assuming an overhead mobile hosereel–raingun system applying river water, abstracted either in summer and used directly, or abstracted in winter and stored in an on-farm reservoir. The results suggest that the yield benefit would justify supplemental irrigation by farmers who have unused irrigation equipment and unused summer water, although irrigation of higher-value field vegetable crops later in the season would normally take precedence – the Added Value of Water (AVW) usefully applied to milling winter wheat under these conditions ranged between 0.24 and 0.32 £ m−3. Investment in new irrigation schemes could also be marginally viable if unused summer river water was available for direct abstraction (AVW = 0.08 £ m−3). Investments in new farm reservoirs for irrigating wheat are currently not profitable (AVW = –0.23 £ m−3). Sensitivity analysis suggests that in the longer term, the expected increase in world wheat prices and the impacts of climate change are likely to make the financial benefits stronger, particularly in the drier catchments further east and on low moisture retentive soils, but competing demands for water would still make extensive wheat irrigation unlikely

Assessing the financial and environmental impacts of precision irrigation in a humid climate

Precision agriculture is increasingly used where in-field spatial variability exists; however, the benefits of its use in humid climates are less apparent. This paper reports on a cost-benefit assessment of precision irrigation with variable rate technique (VRI) versus conventional irrigation, both compared to rainfed production, using a travelling hose-reel irrigator fitted with a boom on onions in eastern England. Selected environmental outcomes including water savings and CO2e emissions are evaluated. The modelled precision irrigation system, which responds to soil variability, generates better environmental outcomes than the conventional system in terms of water savings and reduced CO2e emissions (22.6% and 23.0% lower, respectively). There is also an increase in the ‘added value’ of the irrigation water used (£3.02/m3 versus £2.36/m3). Although precision irrigation leads to significant financial benefits from water and energy savings, these alone do not justify the additional equipment investment costs. However, any changes in yield or quality benefits, equipment costs or greater soil variability than on this site would make investment in precision irrigation more viable

Essential irrigation and the economics of strawberries in a temperate climate

Strawberries are a high value crop in the UK soft fruit sector, with the majority of production grown at field-scale and under protected (polytunnel) conditions. Despite its importance to the rural economy, there is surprisingly little published scientific evidence on the economics of irrigated strawberry production and the value of water in this horticultural sector. A survey of growers, supplemented by secondary data and industry sources, shows considerable variation in key physical and financial performance indicators, both within and between different strawberry production systems, as well as evidence of good practice. Water application depths ranged widely from 800 to over 2000 m3 ha−1 according to grower and crop variety. Irrigation costs typically range between £1.30 and £2.50 m−3 of water applied, highest where storage reservoirs and public water supplies are used. The average value of irrigation water for strawberry net of costs was about £6 m−3, much higher than for field crops such as potatoes. The importance of a reliable water supply to support irrigated strawberry production is highlighted. Climate change and growing pressures on water resources are likely to force a greater interest in irrigation economics in the soft fruit sector, especially in the face of restrictions on summer abstraction and rising competition and charges for using public water supply

Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes

Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific proteolytic target and essential structural protein inside Ca2+ release units required for excitation-contraction coupling in cardiomyocytes. While downregulation of JP2 by Calpain cleavage in heart failure has been reported, the precise molecular identity of the Calpain cleavage sites and the (patho-)physiological roles of the JP2 proteolytic products remain controversial. We systematically analyzed the JP2 cleavage fragments as function of Calpain-1 versus Calpain-2 proteolytic activities, revealing that both Calpain isoforms preferentially cleave mouse JP2 at R565, but subsequently at three additional secondary Calpain cleavage sites. Moreover, we identified the Calpain-specific primary cleavage products for the first time in human iPSC-derived cardiomyocytes. Knockout of RyR2 in hiPSC-cardiomyocytes destabilized JP2 resulting in an increase of the Calpain-specific cleavage fragments. The primary N-terminal cleavage product NT1 accumulated in the nucleus of mouse and human cardiomyocytes in a Ca2+-dependent manner, closely associated with euchromatic chromosomal regions, where NT1 is proposed to function as a cardio-protective transcriptional regulator in heart failure. Taken together, our data suggest that stabilizing NT1 by preventing secondary cleavage events by Calpain and other proteases could be an important therapeutic target for future studies

Process mapping strategies to prevent subcutaneous implantable cardioverter-defibrillator infections

Background: Infection remains a major complication of cardiac implantable electronic devices and can lead to significant morbidity and mortality. Implantable devices that avoid transvenous leads, such as the subcutaneous implantable cardioverter-defibrillator (S-ICD), can reduce the risk of serious infection-related complications, such as bloodstream infection and infective endocarditis. While the 2017 AHA/ACC/HRS guidelines include recommendations for S-ICD use for patients at high risk of infection, currently, there are no clinical trial data that address best practices for the prevention of S-ICD infections. Therefore, an expert panel was convened to develop a consensus on these topics. Methods: An expert process mapping methodology was used to achieve consensus on the appropriate steps to minimize or prevent S-ICD infections. Two face-to-face meetings of high-volume S-ICD implanters and an infectious diseases specialist, with expertise in cardiovascular implantable electronic device infections, were conducted to develop consensus on useful strategies pre-, peri-, and postimplant to reduce S-ICD infection risk. Results: Expert panel consensus on recommended steps for patient preparation, S-ICD implantation, and postoperative management was developed to provide guidance in individual patient management. Conclusion: Achieving expert panel consensus by process mapping methodology for S-ICD infection prevention was attainable, and the results should be helpful to clinicians in adopting interventions to minimize risks of S-ICD infection

Trust and Reciprocity: Are Effort and Money Equivalent?

Trust and reciprocity facilitate cooperation and are relevant to virtually all human interactions. They are typically studied using trust games: one subject gives (entrusts) money to another subject, which may return some of the proceeds (reciprocate). Currently, however, it is unclear whether trust and reciprocity in monetary transactions are similar in other settings, such as physical effort. Trust and reciprocity of physical effort are important as many everyday decisions imply an exchange of physical effort, and such exchange is central to labor relations. Here we studied a trust game based on physical effort and compared the results with those of a computationally equivalent monetary trust game. We found no significant difference between effort and money conditions in both the amount trusted and the quantity reciprocated. Moreover, there is a high positive correlation in subjects' behavior across conditions. This suggests that trust and reciprocity may be character traits: subjects that are trustful/trustworthy in monetary settings behave similarly during exchanges of physical effort. Our results validate the use of trust games to study exchanges in physical effort and to characterize inter-subject differences in trust and reciprocity, and also suggest a new behavioral paradigm to study these differences